A key element in the DNA damage response (DDR), homologous recombination (HR), and DNA interstrand crosslink (ICL) repair has been identified by a research team connected to UNIST. The research team expects that their findings will help fight malignant tumors by creating an efficient control environment for chromosome instability (CIN), a key element in the evolution of cancer.
Professors Hongtae Kim and Kyungjae Myung of UNIST’s Department of Biological Sciences, along with Professor Yonghwan Kim and his research team from Sookmyung Women’s University, jointly led the research that resulted in this discovery, which was published in the January 2023 issue of Nucleic Acids Research.x.
Then, they discovered that in mESC lines, TRAIP appears to function as a regulatory factor upstream of both the NEIL3 and FA pathways, which is important for ICL repair. Additionally, they discovered that TRAIP serves as a master regulator and is involved in ICL repair.
The research team stated, “Our findings in conjunction with the mESC lines used in this study will be informative to understand molecular basis of the ICL repair pathways in detail.